«Wenn ich gross bin, will ich Lacan verstehen» Ein kleiner Erfahrungsbericht zum Projekt «Klinisches Arbeiten mit Lacan in und zwischen zwei Sprachen»

Ein kleiner Erfahrungsbericht zum Projekt «Klinisches Arbeiten mit Lacan in und zwischen zwei Sprachen»

Die sexuelle Befreiung und das Problem mit der Lust. Ein Dialog

Der Begriff der «sexuellen Befreiung» ist an die 68er-Bewegung gebunden und findet heute nur noch selten Verwendung. «Frei» gelebte sexuelle Lust gilt nicht mehr als ein Mittel zur Befreiung aus den bürgerlichen Fesseln. Im Gegenteil gilt sie oftmals sogar als Herrschaftsinstrument, besonders wenn es um die Lust der Männer geht. Und wenn im Rahmen von #metoo von «Freiheit» die Rede ist, dann geht es meist um Consent: Um die Freiheit, zu sexuellen Handlungen «Ja» oder «Nein» zu sagen. Geht es bei #metoo um sexuelle Befreiung? Ist die Art, wie wir begehren, an unser Geschlecht gebunden? Und wenn ja, warum? Was bedeutet Consent im Bett und auf der Couch? Diese Fragen wollten die Autorin und der Autor im Dezember 2018 im Rahmen eines Vortrags am Psychoanalytischen Seminar Luzern diskutieren. Dieser ist hier in gekürzter Fassung wiedergegeben

Von jenen, die auszogen, das Analysieren zu lernen. Kommentar zur Diskussion anlässlich der PSZ-Jubiläumsveranstaltung vom 23. September 2017 zum Thema der aktuellen und zukünftigen Vermittlungspraxis am PSZ

Im Beitrag schildern die Moderatorinnen ihre subjektiven Eindrücke der Diskussion

Academic writing retreats for nurses and allied health professionals: developing engagement, dissemination and collaboration opportunities

Background: COVID-19 raised the profile of nursing globally, with widespread recognition of nurses’ valuable roles during the pandemic. Concurrently, the United Kingdom played a crucial role in leading COVID-19 healthcare research breakthroughs. There exists a unique opportunity to capitalise on this momentum to support nurses to become more engaged in, and disseminate, their research widely. One approach to enabling this is through the development of academic writing retreats for nurses. Aim: To report on the development of academic writing retreats to engage nurses in research. Discussion: Four writing retreats were set-up in South England between September 2019 and April 2021. Two were delivered face-to-face on hospital premises and two online due to COVID-19. The retreats provided uninterrupted writing time to draft an academic publication, mentorship, peer support networks and question and answer sessions. . The retreats were attended by 42 health professionals, with over 25 papers published in peer-reviewed journals. The retreats have enabled learning communities to develop, fostering long-term networking opportunities. Mentorship and uninterrupted writing time were rated 4.7 and 4.9 respectively across all retreats (1 for poor, 5 for excellent), with peer support and networking rated 3.3 and 3.9. Conclusion: Academic writing retreats for nurses have widespread benefits, providing nurses with uninterrupted time and space to focus on writing high quality publications and creating networking opportunities through peer support and mentorship channels.  Implications for Practice: Academic writing retreats are a simple, yet effective way to get nurses to engage in research by writing about their own sphere of practice. The retreats continued throughout the COVID-19 pandemic, enabling research to be published that demonstrates the valuable work of nurses across the international healthcare landscape

Specific paucity of unmyelinated C-fibers in cutaneous peripheral nerves of the African naked-mole rat : comparative analysis using six species of Bathyergidae

Please read abstract in article.Deutsche Forschungsgemeinschaft Collaborative Research Center 665. Ewan St. John Smith was supported by an Alexander von Humboldt fellowship.http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1096-9861/ab201

Three aromatic residues are required for electron transfer during iron mineralization in Bacterioferritin

Ferritins are iron storage proteins that overcome problems of toxicity and poor bioavailability of iron by catalysing iron oxidation and mineralization through the activity of a diiron ferroxidase site. Unlike in other ferritins, the oxidized di-Fe3+ site of Escherichia coli bacterioferritin (EcBFR) is stable and therefore does not function as a conduit for the transfer of Fe3+ into the storage cavity, but instead acts as a true catalytic cofactor that cycles its oxidation state while driving Fe2+ oxidation in the cavity. Here we demonstrate that EcBFR mineralization depends on three near-diiron site aromatic residues, Tyr25, Tyr58 and Trp133, and that a transient radical is formed on Tyr25. The data indicate that the aromatic residues, together with a previously identified inner surface iron site, promote mineralization by ensuring the simultaneous delivery of two electrons, derived from Fe2+ oxidation in the BFR cavity, to the di-ferric catalytic site for safe reduction of O2

Systems Biology Analysis of Brucella Infected Peyers Patch Reveals Rapid Invasion with Modest Transient Perturbations of the Host Transcriptome

Brucella melitensis causes the most severe and acute symptoms of all Brucella species in human beings and infects hosts primarily through the oral route. The epithelium covering domed villi of jejunal-ileal Peyer’s patches is an important site of entry for several pathogens, including Brucella. Here, we use the calf ligated ileal loop model to study temporal in vivo Brucella-infected host molecular and morphological responses. Our results document Brucella bacteremia occurring within 30 min after intraluminal inoculation of the ileum without histopathologic traces of lesions. Based on a system biology Dynamic Bayesian Network modeling approach (DBN) of microarray data, a very early transient perturbation of the host enteric transcriptome was associated with the initial host response to Brucella contact that is rapidly averted allowing invasion and dissemination. A detailed analysis revealed active expression of Syndecan 2, Integrin alpha L and Integrin beta 2 genes, which may favor initial Brucella adhesion. Also, two intestinal barrier-related pathways (Tight Junction and Trefoil Factors Initiated Mucosal Healing) were significantly repressed in the early stage of infection, suggesting subversion of mucosal epithelial barrier function to facilitate Brucella transepithelial migration. Simultaneously, the strong activation of the innate immune response pathways would suggest that the host mounts an appropriate protective immune response; however, the expression of the two key genes that encode innate immunity anti-Brucella cytokines such as TNF-a and IL12p40 were not significantly changed throughout the study. Furthermore, the defective expression of Toll-Like Receptor Signaling pathways may partially explain the lack of proinflammatory cytokine production and consequently the absence of morphologically detectable inflammation at the site of infection. Cumulatively, our results indicate that the in vivo pathogenesis of the early infectious process of Brucella is primarily accomplished by compromising the mucosal immune barrier and subverting critical immune response mechanisms.The open access fee for this work was funded through the Texas A&M University Open Access to Knowledge (OAK) Fund

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.

The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD

Systems Biology Analysis of Gene Expression during In Vivo Mycobacterium avium paratuberculosis Enteric Colonization Reveals Role for Immune Tolerance

Survival and persistence of Mycobacterium avium subsp. paratuberculosis (MAP) in the intestinal mucosa is associated with host immune tolerance. However, the initial events during MAP interaction with its host that lead to pathogen survival, granulomatous inflammation, and clinical disease progression are poorly defined. We hypothesize that immune tolerance is initiated upon initial contact of MAP with the intestinal Peyer's patch. To test our hypothesis, ligated ileal loops in neonatal calves were infected with MAP. Intestinal tissue RNAs were collected (0.5, 1, 2, 4, 8 and 12 hrs post-infection), processed, and hybridized to bovine gene expression microarrays. By comparing the gene transcription responses of calves infected with the MAP, informative complex patterns of expression were clearly visible. To interpret these complex data, changes in the gene expression were further analyzed by dynamic Bayesian analysis, and genes were grouped into the specific pathways and gene ontology categories to create a holistic model. This model revealed three different phases of responses: i) early (30 min and 1 hr post-infection), ii) intermediate (2, 4 and 8 hrs post-infection), and iii) late (12 hrs post-infection). We describe here the data that include expression profiles for perturbed pathways, as well as, mechanistic genes (genes predicted to have regulatory influence) that are associated with immune tolerance. In the Early Phase of MAP infection, multiple pathways were initiated in response to MAP invasion via receptor mediated endocytosis and changes in intestinal permeability. During the Intermediate Phase, perturbed pathways involved the inflammatory responses, cytokine-cytokine receptor interaction, and cell-cell signaling. During the Late Phase of infection, gene responses associated with immune tolerance were initiated at the level of T-cell signaling. Our study provides evidence that MAP infection resulted in differentially regulated genes, perturbed pathways and specifically modified mechanistic genes contributing to the colonization of Peyer's patch

昭和20年代, 教室の日常と研究余話(第922回千葉医学会例会・第13回千葉精神科集談会)

<p>Unique MAA Arcs and Mechanistic Genes in Tight Junction Pathway.</p